Macroautophagy in CNS health and disease
CJ Griffey, A Yamamoto - Nature Reviews Neuroscience, 2022 - nature.com
… of macroautophagy disruption, the degeneration is not widespread. Instead, preferential
vulnerability of neurons to macroautophagy … pyramidal neurons — points to neuronal subtype-…
vulnerability of neurons to macroautophagy … pyramidal neurons — points to neuronal subtype-…
[PDF][PDF] The different autophagy degradation pathways and neurodegeneration
A Fleming, M Bourdenx, M Fujimaki, C Karabiyik… - Neuron, 2022 - cell.com
… Suggested links with psychiatric diseases Recent studies have provided some support for
the hypothesis that altered neuronal macroautophagy may contribute to depression, bipolar …
the hypothesis that altered neuronal macroautophagy may contribute to depression, bipolar …
Autophagy in neuronal development and plasticity
A Fleming, DC Rubinsztein - Trends in neurosciences, 2020 - cell.com
… Within neurons, it helps to remove damaged organelles … neuronal physiology. Here we
review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal …
review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal …
[HTML][HTML] The contribution of altered neuronal autophagy to neurodegeneration
A Filippone, E Esposito, D Mannino, N Lyssenko… - Pharmacology & …, 2022 - Elsevier
… how abnormalities of neuronal autophagy could serve as a pro-degenerative triggering … is
autophagy, in particular macroautophagy. Neuronal macroautophagy prevents cell toxicity by …
autophagy, in particular macroautophagy. Neuronal macroautophagy prevents cell toxicity by …
The autophagy lysosomal pathway and neurodegeneration
S Finkbeiner - Cold Spring Harbor perspectives in …, 2020 - cshperspectives.cshlp.org
… lysosome including nonspecific macroautophagy, substrate-… , in motor neurons early in
development in mice expressing a … unit function and motor neuron-dependent phenotypes could …
development in mice expressing a … unit function and motor neuron-dependent phenotypes could …
[HTML][HTML] Macroautophagy and mitophagy in neurodegenerative disorders: Focus on therapeutic interventions
JD Magalhães, L Fão, R Vilaça, SM Cardoso, AC Rego - Biomedicines, 2021 - mdpi.com
… Neuronal macroautophagy is an important mechanism that removes faulty intracellular
materials, being extremely efficient in neurons, … to halt neuronal dysfunction and degeneration. …
materials, being extremely efficient in neurons, … to halt neuronal dysfunction and degeneration. …
[HTML][HTML] Regulation of neuronal autophagy and the implications in neurodegenerative diseases
… Thus, neurons rely heavily on autophagy that constitutes a … located in the soma of neurons,
the robust, constitutive … of the roles of autophagy in neuronal health and disease. We …
the robust, constitutive … of the roles of autophagy in neuronal health and disease. We …
The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy
… (neuro)developmental phenotypes and the predilection for certain (neuronal) tissues in the
… , 2) a combination of developmental and degenerative abnormalities evolving over time and 3…
… , 2) a combination of developmental and degenerative abnormalities evolving over time and 3…
[HTML][HTML] Macroautophagy and normal aging of the nervous system: Lessons from animal models
E Kallergi, V Nikoletopoulou - Cell stress, 2021 - ncbi.nlm.nih.gov
… monitoring autophagy in cultured neurons and in the nervous … on neuronal integrity and on
neuronal macroautophagy, as … progressive degeneration of hippocampal pyramidal neurons, …
neuronal macroautophagy, as … progressive degeneration of hippocampal pyramidal neurons, …
[HTML][HTML] mTOR suppresses macroautophagy during striatal postnatal development and is hyperactive in mouse models of autism spectrum disorders
OJ Lieberman, V Cartocci, I Pigulevskiy… - Frontiers in Cellular …, 2020 - frontiersin.org
… Macroautophagy (hereafter referred to as autophagy) plays a critical role in neuronal function
related to development and degeneration. … during striatal postnatal development, reaching …
related to development and degeneration. … during striatal postnatal development, reaching …